Spyre Therapeutics, Inc. — Institutional Ownership
Which tracked institutions hold SYRE, and how they changed the position last quarter. Latest holdings as of Jun 30, 2026. Source: SEC 13-F filings.
29
Funds holding
$1757052184
Total value held
Buying
27 added/new · 2 reduced
| # | Institution | Value | Shares | Δ Shares | Change (QoQ) |
|---|---|---|---|---|---|
| 1 | Blackrock, Inc. | $577656391 | 6506605 | +985384 | +17.85% |
| 2 | State Street Corp | $271437392 | 3057416 | +450385 | +17.28% |
| 3 | Bank Of America Corp /De/ | $157837878 | 1777854 | +549761 | +44.77% |
| 4 | Goldman Sachs Group Inc | $131222079 | 1478059 | +1208121 | +447.55% |
| 5 | Franklin Resources Inc | $130767861 | 1472943 | +590110 | +66.84% |
| 6 | Jpmorgan Chase & Co | $98870628 | 1093026 | +113727 | +11.61% |
| 7 | Janus Henderson Group Plc | $83586597 | 1656164 | +1656164 | NEW BUY |
| 8 | Ubs Group Ag | $74847843 | 843071 | +843071 | NEW BUY |
| 9 | Northern Trust Corp | $59884685 | 674529 | +95622 | +16.52% |
| 10 | Morgan Stanley | $44386718 | 499963 | +253244 | +102.64% |
| 11 | Ameriprise Financial Inc | $31612960 | 356082 | +356082 | NEW BUY |
| 12 | Bank Of New York Mellon Corp | $21768235 | 245193 | +53798 | +28.11% |
| 13 | Invesco Ltd. | $10701630 | 120541 | +120541 | NEW BUY |
| 14 | Blackstone Inc. | $10669314 | 120177 | +120177 | NEW BUY |
| 15 | Barclays Plc | $8351446 | 94069 | +48283 | +105.45% |
| 16 | Prudential Financial Inc | $7756709 | 87370 | +27815 | +46.70% |
| 17 | Federated Hermes, Inc. | $7630641 | 85950 | +85950 | NEW BUY |
| 18 | Citigroup Inc | $7332606 | 82593 | -17465 | -17.45% |
| 19 | Wells Fargo & Company/Mn | $7324883 | 82506 | +49298 | +148.45% |
| 20 | Principal Financial Group Inc | $5304339 | 59747 | +55448 | +1289.79% |
| 21 | Raymond James Financial Inc | $4761005 | 53627 | +33872 | +171.46% |
| 22 | Fifth Third Bancorp | $1388350 | 15638 | +15633 | +312660.00% |
| 23 | Sei Investments Co | $1237682 | 13941 | +4966 | +55.33% |
| 24 | Stifel Financial Corp | $267316 | 3011 | +3011 | NEW BUY |
| 25 | Royal Bank Of Canada | $208000 | 2338 | -912 | -28.06% |
| 26 | Us Bancorp \De\ | $133791 | 1507 | +1410 | +1453.61% |
| 27 | Pnc Financial Services Group, Inc. | $81145 | 914 | +791 | +643.09% |
| 28 | Toronto Dominion Bank | $23971 | 270 | +270 | NEW BUY |
| 29 | Zions Bancorporation, National Association /Ut/ | $89 | 1 | +1 | NEW BUY |
Aggregated across tracked institutional filers. Reported quarterly on SEC Form 13-F and may lag. For research only — not investment advice.