Spyre Therapeutics, Inc. — Institutional Ownership
Which tracked institutions hold SYRE, and how they changed the position last quarter. Latest holdings as of Mar 31, 2026. Source: SEC 13-F filings.
23
Funds holding
$705844247
Total value held
Buying
19 added/new · 4 reduced
| # | Institution | Value | Shares | Δ Shares | Change (QoQ) |
|---|---|---|---|---|---|
| 1 | Blackrock, Inc. | $278490385 | 5521221 | -880 | -0.02% |
| 2 | State Street Corp | $131498644 | 2607031 | +344192 | +15.21% |
| 3 | Janus Henderson Group Plc | $83586597 | 1656164 | — | NEW BUY |
| 4 | Bank Of America Corp /De/ | $61945011 | 1228093 | +808366 | +192.59% |
| 5 | Franklin Resources Inc | $44530096 | 882833 | -226441 | -20.41% |
| 6 | Northern Trust Corp | $29200068 | 578907 | +17884 | +3.19% |
| 7 | Blackstone Inc. | $14771203 | 292847 | — | NEW BUY |
| 8 | Goldman Sachs Group Inc | $13615673 | 269938 | -5127 | -1.86% |
| 9 | Morgan Stanley | $12444525 | 246719 | +63985 | +35.02% |
| 10 | Bank Of New York Mellon Corp | $9653965 | 191395 | -1435 | -0.74% |
| 11 | Ameriprise Financial Inc | $8030906 | 159217 | +120961 | +316.19% |
| 12 | Invesco Ltd. | $4944597 | 150934 | +100232 | +197.69% |
| 13 | Citigroup Inc | $3277900 | 100058 | +67162 | +204.16% |
| 14 | Prudential Financial Inc | $3003954 | 59555 | — | NEW BUY |
| 15 | Wells Fargo & Company/Mn | $2699948 | 82416 | +43097 | +109.61% |
| 16 | Barclays Plc | $2309445 | 45786 | — | NEW BUY |
| 17 | Raymond James Financial Inc | $996442 | 19755 | — | NEW BUY |
| 18 | Sei Investments Co | $452699 | 8975 | — | NEW BUY |
| 19 | Principal Financial Group Inc | $216841 | 4299 | — | NEW BUY |
| 20 | Royal Bank Of Canada | $164000 | 3250 | — | NEW BUY |
| 21 | Pnc Financial Services Group, Inc. | $6204 | 123 | +37 | +43.02% |
| 22 | Us Bancorp \De\ | $4892 | 97 | +87 | +870.00% |
| 23 | Fifth Third Bancorp | $252 | 5 | — | NEW BUY |
Aggregated across tracked institutional filers. Reported quarterly on SEC Form 13-F and may lag. For research only — not investment advice.